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Tekmira Ebola drug succeeds in small monkey study

REUTERS by Aharon Begley                                                                    Aug. 22, 2015
NEW YORK --An experimental Ebola drug from Tekmira Pharmaceuticals Corp cured all three monkeys intentionally infected with the virus, scientists reported on Wednesday, the first such success against the strain of Ebola in West Africa's 2014-2015 outbreak.

Although other experimental treatments appeared to help Ebola patients last year, especially in the United States, those one-time uses cannot prove efficacy against the "Makona" strain, since patients' recovery might be due to other causes. Similarly, drugs, including Mapp Biopharmaceutical's ZMapp, cured monkeys in lab experiments, but in a strain of Ebola different from that responsible for the current outbreak, the worst ever recorded.

"We can't say for certain that an experimental drug that works against one strain will work in another, even if they're almost identical genetically," said Thomas Geisbert of the University of Texas Medical Branch, senior author of the study published in the journal Nature.

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2 new ebola vaccines pass important early test, researchers say

NEW YORK TIMES   by Denis Grady                                                                 April 9. 2015

Two  new Ebola vaccines have passed an important test, protecting monkeys against the strain of the virus responsible for the current deadly outbreak, researchers reported on Wednesday. Only one dose was needed, and there were no apparent side effects..

Thomas W. Geisbert, an Ebola expert at the University of Texas Medical Branch in Galveston, in his office. Credit Michael Stravato for The New York Times

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Exclusive: take a first look at the next generation ebola-protection suit

QUARTZ  by Grace Dobush                                         March 13, 2015

AUSTIN, Texas—Perhaps the most surprising and important product debuting at SXSW Interactive this year is a personal protective equipment (PPE) prototype for health care workers dealing with Ebola, a tangible result of the U.S. government adapting the culture of innovation and design thinking so key in the startup world.

A team from the U.S. Agency for International Development demonstrated the traditional Ebola suit and the new suit in a preview for Quartz....

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Report Slams U.S. Ebola Response and Readiness

NBC NEWS  by Maggie Fox                                                                               Feb. 26, 2015

The United States fumbled its response to the Ebola epidemic before it even began, neglecting experiments to make vaccines and drugs against the virus, and cutting funding to key public health agencies, a presidential commission said Thursday.

Americans focused on their own almost nonexistent risk of catching Ebola from travelers instead of pressing to help the truly affected nations, the scathing report from the Presidential Commission for the Study of Bioethical Issues says.

They've been acting against their own best interest, the commission said in its report.

"Both justice and prudence demand that we do our part in combating such devastating outbreaks. Once we recognize our humanitarian obligations and the ability of infectious diseases to travel in our interconnected world, we cannot choose between the ethical and the prudential," it reads.

"Ethics and enlightened interest converge in calling for our country to address epidemics at their source."

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New CDC report offers insight into Dallas County Ebola outbreak

THE DALLAS MORNING NEWS                                                                               Nov. 15, 2014

By Sherry Jacobson

The “Ebola cluster” in Dallas County is the subject of the Morbidity and Mortality Weekly Report published Friday by the Centers for Disease Control and Prevention.

...the report offers a detailed timeline of what happened, starting with Thomas Eric Duncan’s arrival in Dallas from Liberia on Sept. 20. His Ebola symptoms were misdiagnosed Sept. 25 at Texas Health Presbyterian Hospital Dallas as sinusitis and he was sent home with antibiotics. He returned to the hospital Sept. 28, underwent 10 days of treatment and died Oct. 8.

Two of Duncan’s caretakers, both registered nurses, were also infected and were treated successfully for the disease. Protocols required public health workers to monitor 177 people who had contact with the three Ebola patients.

A dozen people in that group, however, were tested for Ebola after developing fever or other symptoms compatible with the disease during the monitoring period. None were found to have Ebola. By last Friday, all contacts had cleared 21 days of monitoring and the county’s outbreak was declared over.

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Military names 5 U.S. bases for troop Ebola quarantines

ASSOCIATED PRESS                                              Nov. 7, 2014
WASHINGTON -- The top U.S. military officer has designated five U.S. bases where American troops would be housed and isolated for 21 days upon returning from Africa after serving in the Ebolaresponse mission, U.S. officials said Friday.

Army Gen. Martin Dempsey, the chairman of the Joint Chiefs of Staff, signed a plan that lists Fort Hood and Fort Bliss, Texas; Fort Bragg, North Carolina; Joint Base Lewis-McChord, Washington; and Joint Base Langley-Eustis, Virginia, as bases where troops would be quarantined.

The U.S. also will use two bases in Italy and Germany for returning troops based in that region....

The plan exempts military personnel who travel to Africa for short-term visits and have very limited contact with people there, such as military staff traveling with a senior official who only stops in the country for a day or two...

In a related announcement, U.S. Northern Command has decided to train 30 more medical support personnel who will be available to help U.S. hospitals with any future Ebola cases. The personnel will begin training in San Antonio, Texas, later this month and will supplement a 30-member team that has already been trained and is ready to respond.

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Last Person Completes Ebola Monitoring in Texas

ABC NEWS                                                                                                            Nov 7, 2014

by  Sydney Ludkin 

DALLAS The final person in Texas being monitored for Ebola has passed the virus's 21-day incubation period, marking the end of the state's Ebola crisis.

None of the 177 people who had contact with the state's Ebola patients -- Liberian national Thomas Eric Duncan, the first person to be diagnosed with Ebola in the United States, and two of the Dallas nurses who cared for him, Nina Pham and Amber Vinson -- have contracted Ebola, state officials said. The list included health care workers, people who shared the same households as the Ebola patients and other community contacts.

"Hopefully, Americans will be relieved and fear will be eased," said Dr. Richard Besser, ABC News chief health and medical editor. "In Dallas, not even the people who lived with a very sick person with Ebola became ill."

Read complete story

http://abcnews.go.com/Health/person-completes-ebola-monitoring-texas/story?id=26742640

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UT nasal spray vaccine for Ebola effective in monkeys

By Todd Ackerman                                                                           Nov. 5, 2014

... researchers at the University of Texas-Austin have developed a nasal spray vaccine that has protected monkeys against the deadly Ebola virus even a year after immunization.

The vaccine, a genetically engineered cold virus containing a tiny portion of Ebola DNA, saved 100 percent of monkeys who got a single spray through the nose in a new UT study. Injecting the vaccine only saved the lives of about 50 percent.

 
 
 Maria Croyle, a professor of pharmaceutics and the study's principal investigator, said an inhaled Ebola vaccine is more attractive because it would be cheaper and safer than needle-delivered vaccines.

"The main advantage is the long-lasting protection after a single inhaled dose," Maria Croyle, a  professor of pharmaceutics and the study's principal investigator, said in a statement. "This is important since the longevity of other vaccines for Ebola (hasn't been) fully evaluated....

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