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Zika Linked to Rising Tide of Serious Neurologic Complications in Adults

CLICK HERE - JAMA Neurology - Neurologic Complications Associated With the Zika Virus in Brazilian Adults

medscape.com - by Nancy A. Melville - August 15, 2017

A rising tide of serious neurologic complications among adults in Brazil has been linked to the spread of the Zika virus, new research shows.

"Our study is the first prospective study assessing the occurrence of neurological complications in adults secondary to Zika virus infection, with all previous data based solely on case series and case reports," senior author, Osvaldo Jose Moreira do Nascimento, MD, PhD, from the Neurology Department at Universidade Federal Fluminense, Copacabana, Rio de Janeiro, Brazil, told Medscape Medical News.

"We observed an increase in the admissions of patients with inflammatory complications, such as Guillain-Barré syndrome (GBS), myelitis and encephalitis."

The study was published online August 14 in JAMA Neurology.

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CLICK HERE - Neurological complications associated with Zika virus in adults in Brazil

 

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Texas Doctors Under-Test for Zika

CLICK HERE - CDC MMWR - Notes from the Field: Zika Virus-Associated Neonatal Birth Defects Surveillance — Texas, January 2016–July 2017

Zika birth defects reported in 8% of zika infected Texas mothers

zikanews.com - by Don Ward - August 12, 2017

Zika virus testing for both travel-related cases and local transmission, need increased surveillance from Texas physicians, according to the Centers for Disease Control and Prevention (CDC).

A recent CDC analysis found that 57% of infants or fetuses for whom Zika testing was indicated, did not receive tests.

This is important because 8% of Texas infants or fetal losses were delivered with lab-confirmed Zika.

The Texas birth defect rate of 8% compares with 5.5% for the entire USA, and 4.4% in USA territories.

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Texas Reports First Locally Transmitted Case of Zika in US This Year

                                                    

CLICK HERE - Texas Department of State Health Services - Health officials find probable local Zika infection - July 26, 2017

cnn.com - by Debra Goldschmidt - July 26, 2017

A resident of Hidalgo County, Texas who has now recovered from the Zika virus was probably infected within the county, local and state health officials said Wednesday. This represents the first locally transmitted case of the virus reported in the continental United States this year.

"Because the individual has not recently traveled outside the area or had any other risk factors, the infection was probably transmitted by a mosquito bite in South Texas sometime in the last few months," according to a joint statement from the Texas Department of State Health Services and Hidalgo County Health and Human Services.

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Hotez Measles Prediction: Something Awful is Happening in Texas

CLICK HERE - PLOS - Texas and Its Measles Epidemics

outbreaknewstoday.com - by Robert Herriman - July 15, 2017

The Dean for the National School of Tropical Medicine, Baylor College of Medicine, Dr Peter Hotez is concerned about measles in his state of Texas, so much that he is raising the alarm by predicting a measles outbreak could happen as early as the winter or spring of 2018.

In an article published in PLoS Medicine last fall, Hotez writes: Measles vaccination coverage in certain Texas counties is dangerously close to dropping below the 95% coverage rate necessary to ensure herd immunity and prevent measles outbreaks.

He tells me during the interview, “Something awful is happening in Texas,” Dr Hotez said.

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Uptick in Creutzfeld-Jakob Cases Raises Questions

Is chronic wasting disease in deer making the jump to humans?

medpagetoday.com - by MedPage Today Staff - July 10, 2017

Cases of Creutzfeldt-Jakob disease, the fatal prion disease that's closely related to "mad cow" disease, have risen in Wisconsin and nationally in recent years, according to the Milwaukee Journal Sentinel.

In Wisconsin, there were six cases in 2002, but in two of the last four years, 13 cases have been reported -- which could be attributed to better surveillance, local officials said. Yet the increase tracks with data on chronic wasting disease among deer in the state, raising concerns about whether the illness is jumping from animals to humans.

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CLICK HERE - Milwaukee Journal Sentinel - Can chronic wasting disease jump from deer to humans? Concerns keep rising

 

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Climate Change Pushing Tropical Diseases Toward Arctic

Temperature changes around the globe are pushing human pathogens of all kinds into unexpected new areas, raising many new risks for people.

           

Bathers on the Baltic have recently been confronted with a new threat: dangerous disease that is normally only found in warm water.  PHOTOGRAPH BY PRIIT VESILIND, NATIONAL GEOGRAPHIC CREATIVE

news.nationalgeographic.com - by Craig Welch - June 14, 2017

 . . . It's no secret that climate change can spread illnesses such as West Nile virus, Zika, and malaria, as rising temperatures push disease-carrying mosquitoes into new places, from the highlands of Ethiopia to the United States. But warm temperatures and shifting weather patterns work in subtle ways, too. Changes in precipitation, wind, or heat are shifting the threat posed by other human illnesses, from cholera to a rare freshwater brain-eating amoeba to rodent-driven infections like hantavirus. And the importance of all these changes are only growing more significant.

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Miami's Zika Outbreak Began Months Before It Was First Detected

           

A groundskeeper at Pinecrest Gardens sprays pesticide to kill mosquitoes in Miami-Dade County, Fla., in 2016.  Gaston De Cardenas/Miami Herald/TNS via Getty Images

CLICK HERE - STUDY - Nature - Genomic epidemiology reveals multiple introductions of Zika virus into the United States

npr.org - by Greg Allen - May 24, 2017

Last year's Zika outbreak in Miami likely started in the spring of 2016, with the virus introduced multiple times before it was detected, researchers say. And most of those cases originated in the Caribbean.

The study, published Wednesday in Nature, examined more than 250 cases of local Zika transmission in three Miami neighborhoods. Researchers analyzed 39 Zika virus genomes isolated from 32 people who had been infected and seven Aedes aegypti mosquitoes, the species that carries Zika.

Comparison of differences in those genomes finds the virus was introduced by travelers at least four and perhaps as many as 40 different times as early as March 2016. Local transmission of Zika wasn't confirmed in Miami until late July.

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New Zika Virus Inhibitor Identified

CLICK HERE - RESEARCH - Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists

business-standard.com - ANI - May 17, 2017

A new research has brought a drug to treat Zika infections closer to reality.

The team led by Alexey Terskikh and Alex Strongin from Sanford Burnham Prebys Medical Discovery Institute (SBP) discovered a compound that prevents the virus from spreading.

"We identified a small molecule that inhibits the Zika virus protease, and show that it blocks viral propagation in human cells and in mice," Terskikh said. "Anti-Zika drugs are desperately needed. The fact that the compound seems to work in vivo is really promising, so we plan to use it as a starting point to make an even more potent and effective drug."

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US May Be Severely Underestimating Zika's Potential Impact; Costs Could Be in the Billions

Deadly carriers of disease: Aedes aegypti mosquitoes.  Paulo Whitaker | Reuters

Gulf Coast region is vulnerable to Zika attacks

Congress may not appreciate full extent of potential damage

Conservative calculations suggest full impact could exceed $2 billion

CLICK HERE - PLOS - The potential economic burden of Zika in the continental United States

cnbc.com - by Robert Ferris - May 11, 2017

The Zika virus stands to cost the United States billions of dollars, even if few people are infected.

Researchers from several American institutions have calculated that the "virus from Hell" could result in total costs ranging from $183 million to over $1.2 billion, depending on infection rates in several at-risk states in the South.

The researchers warn that infection rates could engender costs that exceed the amounts of money the U.S. government may give for prevention and treatment, if the recent debates over funding are any indication.

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Zika Testing Recommendations Changed for Pregnant Women

           

A nurse practitioner gives a pregnant woman insecticide and information about Zika at a Miami clinic last summer.  LYNNE SLADKY/AP

CLICK HERE - CDC - Health Alert Network (HAN) - Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women

statnews.com - by Helen Branswell - May 5, 2017

 . . . Testing for Zika infection is becoming more difficult, making it harder for doctors to advise pregnant women about the chances their child might have a Zika-related birth defect, the Centers for Disease Control and Prevention revealed in a health advisory issued Friday.

The CDC is now suggesting that women thinking of getting pregnant, and who may be exposed to the Zika virus through travel or because of where they live, should consider having their blood tested for Zika antibodies before they get pregnant. Having a baseline reading would help to interpret Zika tests done during a later pregnancy.

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