Health

Juan Pedro, who has microcephaly and turned one-year-old on December 4, sits in a specially designed chair to keep him upright as he is kissed by his sister Jennifer Karine on December 12, 2016 in Recife, Brazil. As many of the babies with microcephaly, believed to be linked to the Zika virus, turn one-year-old in Recife, doctors and mothers are adapting and learning treatments to assist and calm the children. Many of the children are suffering a plethora of difficulties including vision and hearing problems with doctors now labeling the overall condition as 'Congenital Zika Syndrome'. (Photo by Mario Tama/Getty Images)

CLICK HERE - STUDY - NEJM - Zika Virus Infection in Pregnant Women in Rio de Janeiro

forbes.com - by Tara Haelle - December 14, 2016

The rate of birth defects, disability and brain irregularities in babies exposed to the Zika virus is considerably higher than was previously believed — regardless of the mother’s symptoms or the trimester she had the infection — found a new study . . .

Infection of developing human brain with the Zika virus (green) highlights susceptibility of radial glial cells during fetal development. Image by Elizabeth Di Lullo

CLICK HERE - STUDY - PNAS - Zika virus cell tropism in the developing human brain and inhibition by azithromycin

ucsf.edu - by Laura Kurtzman - November 29, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, can prevent the virus from infecting these cells . . .

 . . . In the new study, published online Nov. 29, 2016, in the Proceedings of the National Academy of Sciences (PNAS), the UCSF researchers determined that the Zika virus preferentially infects brain cells with an abundance of a protein called AXL, which spans the outer cell membrane of several cell types and serves as a gateway for the invading virus . . . 

A 1-year-old child, one of the patients in a new study, showed clear signs of microcephaly, but also had good eye contact. Credit van der Linden V, Pessoa A, et al. MMWR: 11.22.2016

nytimes.com - by Pam Belluck - November 22, 2016

It is the news that doctors and families in the heart of Zika territory had feared: Some babies not born with the unusually small heads that are the most severe hallmark of brain damage as a result of the virus have developed the condition, called microcephaly, as they have grown older.

The findings were reported in a study of 13 babies in Brazil that was published Tuesday in Morbidity and Mortality Weekly Report. At birth, none of the babies had heads small enough to receive a diagnosis of microcephaly, but months later, 11 of them did . . . 

 . . . The new study echoes another published this fall, in which three babies were found to have microcephaly later in their first year.

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A researcher holds a tray of Zika virus growing in cells at Washington University School of Medicine in St. Louis. No treatments exist to block Zika virus in a pregnant woman from infecting her fetus and potentially causing severe birth defects. But now, researchers report that they have identified a human antibody that prevents -- in pregnant mice -- the fetus from becoming infected and damage to the placenta. The antibody also protects adult mice from Zika disease.  Photo: Huy Mach

CLICK HERE - Nature - Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

nbcnews.com - by Maggie Fox - November 7, 2016

Researchers reported two steps toward fighting the Zika virus Monday — one from a team that has found a potential way to protect unborn babies from the virus, and a second from a team that announced the start of human trials of a new vaccine.

Neither offers immediate relief against the epidemic of Zika that has swept across the Americas and the Caribbean and parts of Asia, but they both provide hope of eventually being able to protect pregnant women and their babies from the infection.