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PositiveID Successfully Detects the Zika Virus on its Firefly Dx Prototype System

PositiveID uses assay partner GenArraytion's Zika test, the first commercially available multi-plexed PCR-based molecular test to identify dual lineages of the Zika virus

investors.positiveidcorp.com - May 25, 2016

DELRAY BEACH, Fla., May 25, 2016 (GLOBE NEWSWIRE) -- PositiveID Corporation ("PositiveID" or "Company") (OTCQB:PSID), a life sciences company focused on detection and diagnostics, announced today that it has successfully detected the Zika virus on its Firefly Dx polymerase chain reaction ("PCR") breadboard prototype pathogen detection system ("prototype system"). . .

. . . PositiveID used assay partner GenArraytion, Inc.'s Aedes Aegypti MultiFLEX™ Bioassay test, which targets four genetic regions of the Zika virus, on PositiveID's Firefly Dx prototype system. The Zika virus test works with an existing GenArraytion MultiFLEX™ Bioassay panel that targets viruses that cause dengue fever, yellow fever and Chikungunya, which are also carried by the same mosquito and are known to cause febrile disease in humans.  This test both identifies and discriminates between the Zika African and Brazilian lineages.

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Culex Mosquitoes Do Not Transmit Zika Virus, Kansas State University Study Finds

Culex mosquitoes do not appear to transmit Zika virus, according to research at Kansas State University's Biosecurity Research Institute.

CLICK HERE - RESEARCH - Culex Species Mosquitoes and Zika Virus

k-state.edu - September 22, 2016

A Biosecurity Research Institute study has found important results in the fight against Zika virus: Culex mosquitoes do not appear to transmit Zika virus.

Researchers at Kansas State University's Biosecurity Research Institute studied Culex species mosquitoes from across the country, including Vero Beach in Florida, which is near Miami-Dade County where mosquitoes are spreading Zika virus. 

The research, "Culex species mosquitoes and Zika virus," appears in the journal Vector-Borne and Zoonotic Diseases and involves researchers from Rutgers University, the University of Florida and the U.S. Department of Agriculture.

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Zika: Scientists Warn of Global Microcephaly 'Epidemic' After Study Shows Strong Links to Virus

A baby with microcephaly at a rehabilitation centre in Recife, Brazil.  Reuters: Ueslei Marcelino

CLICK HERE - The Lancet Infectious Diseases - Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study

abc.net.au - AFP - September 15, 2016

Scientists are warning that the world should prepare for a "global epidemic" of microcephaly, a birth defect where a baby's head is smaller than usual, as the Zika virus spreads to new countries.

Key points:

Researchers say microcephaly epidemic will spread to all countries with Zika

Scientists recommend Zika be added to list of congenital birth infections

Not all study babies with microcephaly had abnormalities show in brain scans

The warning comes after researchers in Brazil and Britain found further evidence to link the condition with Zika virus, a connection already widely accepted in medical circles.

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What Doctors Learned From 42 Infants With Microcephaly

           

Infants born with microcephaly are held by mothers at a meeting for mothers of children with special needs in Recife, Brazil.  Mario Tama/Getty Images

CLICK HERE - CDC - Emerging Infectious Diseases (EID) - Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

npr.org - by Susan Brink - September 14, 2016

"These babies do not catch up as they grow," says Dr. Antonia Augusto Moura da Silva of the Federal University of Maranhao, Sao Luis, Brazil.

He's describing the findings from a study of 48 babies whose mothers were believed to have been infected with the Zika virus. Forty-two of the children were diagnosed with microcephaly. The study, on the early neurological growth pattern of the infants, will be published in the journal Emerging Infectious Diseases in November but was released early online.

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As Zika Spreads In Asia, Study Shows Virus May Also Infect Adult Brain Cells

           

A new study demonstrates that Zika can affect adult brain cells in mice, suggesting that the effects of Zika could be bigger than currently presumed. (YURI CORTEZ/AFP/Getty Images)

CLICK HERE - Cell Stem Cell - Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

CLICK HERE - Singapore - Minister of Health (MOH) - Sequencing of Zika Virus Strains From Sims Drive/ Aljunied Crescent Cluster

forbes.com - by Tim Chen - September 12, 2016

As concerns rise over the spread of the Zika virus in Southeast Asia, a new study from the Rockefeller University, published in Cell Stem Cell, found that the virus can also affect adult brain cells in mice — suggesting the potential for Zika to hold long-term neurological implications for adult humans.

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2.6 Billion People Could Be at Risk of Zika, Scientists Say

           

A pest control worker fumigates the grounds of a residential estate in the Bedok North area of Singapore on Sept. 1, 2016.  Roslan Rahman—AFP/Getty Images

CLICK HERE - Potential for Zika virus introduction and transmission in resource-limited countries in Africa and the Asia-Pacific region: a modelling study

time.com - by Maria Cheng - September 1, 2016

Scientists are trying to figure out where Zika might gain a future foothold

(LONDON) — Scientists trying to predict the future path of Zika say that 2.6 billion people living in parts of Asia and Africa could be at risk of infection, based on a new analysis of travel, climate and mosquito patterns in those regions.

Some of the most vulnerable countries include India, China, the Philippines, Indonesia, Nigeria, Vietnam, Pakistan and Bangladesh, according to the research. . . .

. . . The study was published online Thursday in the journal, Lancet.

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WHO - Zika Causality Statement - 7 September 2016

                                                  

who.int - 7 September 2016

Zika virus infection: update on the evidence for a causal link to congenital brain abnormalities and Guillain-Barré syndrome

Update of WHO Statement published on 31 March 2016

Since 2013, an unexpected rise in the number of reported cases of the neurological disorder Guillain-Barré syndrome2 (GBS) in French Polynesia, Brazil and other countries in the Americas led specialists to infer a link with an ongoing outbreak of Zika virus infection. Reports of unexpected increases in cases of microcephaly in north-eastern Brazil also led to the suggestion of a link to Zika virus infection in late 2015. On 1 December 2015, PAHO/WHO published an alert regarding the implications for public health of the detection of neurological syndromes and congenital malformations in the context of epidemic transmission of Zika virus in Brazil. On 1 February 2016, the World Health Organization (WHO) declared that the clusters of cases of microcephaly and neurological disorders occurring in areas with Zika virus transmission constituted a public health emergency of international concern.

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The Coming Trials of Generation Zika

           

An Aedes aegypti mosquito. PHOTO: ASSOCIATED PRESS

We may see an increase in the incidence of mental illness, Parkinson’s and dementia.

wsj.com - by W. Ian Lipkin - September 6, 2016

Some four million children are born each year in the U.S., about half in areas where the mosquito species capable of carrying the Zika virus is found. If we assume that 3% of pregnant women in the U.S. will become infected over the next three years and at least 1% of children born to those mothers will be microcephalic, we can anticipate up to 20,000 microcephalic children. Humanitarian considerations aside, the estimated cost of caring for one such child over the course of his lifespan is $10 million.

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CLICK HERE - The White House - Letter From The President - Zika Virus - February 22, 2016

 

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Zika’s Persistence in the Eye May Play a Role in Spreading the Virus, Study Finds

           

Daniele Santos holds her baby Juan Pedro, who has microcephaly, on May 30 in Recife, Brazil. (Mario Tama/Getty Images)

CLICK HERE - Cell Reports - Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears

washingtonpost.com - by Lena H. Sun - September 6, 2016

Researchers have found that the Zika virus can live in eyes, and research in mice may help explain why some Zika patients develop eye disease, including a condition that can lead to permanent vision loss.

In a study published Tuesday in Cell Reports, researchers from Washington University School of Medicine in St. Louis describe the effect of Zika virus infections in the eyes of mouse fetuses, newborns and adults.

The study suggests that the eye could be a reservoir for the virus. Eye infection raises the possibility that people could become infected with Zika through contact with tears from infected people, they said.

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WHO Continues Zika Emergency Amid Virus Spread, Unanswered Questions

cidrap.umn.edu - by Lisa Schnirring  - September 2, 2016

WHO panel cites virus spread, research gaps
CLICK HERE - WHO - Fourth meeting of the Emergency Committee under the International Health Regulations (2005) regarding microcephaly, other neurological disorders and Zika virus 

CDC funds for microcephaly, birth defects
CLICK HERE - CDC awards $2.4 million to five jurisdictions to fight Zika

The World Health Organization (WHO) announced today that its Zika emergency committee, which met yesterday, has recommended keeping the public health emergency in place, as the US Centers for Disease Control and Prevention (CDC) announced $2.4 million in funding to help five of the nation's most populated cities detect and manage Zika-related birth defects.

CDC-Colombia effort, Singapore cases, brain cell infection
In other new Zika developments, the CDC announced a formal research collaboration with Colombia, Singapore reported more Zika cases, and researchers revealed possible differences in brain cell infections between the two Zika lineages.

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