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Dengue Antibodies Enhance Zika Infection?

Dengue-infected tissue - CDC; Frederick Murphy, Cynthia Goldsmith

 

CLICK HERE - STUDY - Dengue Virus Antibodies Enhance Zika Virus Infection

Previous flavivirus infection could help explain the severity of symptoms in some people infected during the ongoing Zika outbreak, researchers report.

The Scientist - by Tanya Lewis - April 28, 2016

Scientists at Florida Gulf Coast University and their colleagues have found that human cells were more likely to be infected with Zika virus in vitro if they contained antibodies to dengue virus. Their findings, detailed Monday (April 25) in a bioRxiv preprint, could help explain why Zika infection appears to be more severe in areas where dengue is endemic, and points to a potential unintended effect of dengue vaccination.

Antibodies to dengue can increase the virus’s infectivity for certain types of immune cells through a process called antibody-dependent enhancement (ADE), resulting in the production of more virus and more severe illness.

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Study Sees Way to Limit Mosquitoes’ Ability to Spread Zika

          

An Aedes Aegypti mosquito photographed on human skin. PHOTO: AGENCE FRANCE-PRESSE/GETTY IMAGES

CLICK HERE - STUDY - Cell Host & Microbe - Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes

Presence of Wolbachia bacterium in the insects seen limiting their ability to transmit the rapidly spreading virus

wsj.com - by REED JOHNSON, ROGERIO JELMAYER, and BETSY MCKAY - May 4, 2016

Introducing a common bacterium into a species of mosquitoes drastically limits the insects’ ability to transmit the dangerous Zika virus that has been spreading rapidly, according to researchers at Brazil’s leading medical-research institute.

In a new study published on Wednesday in the journal Cell Host & Microbe, researchers at the Oswaldo Cruz Foundation (Fiocruz), in Rio de Janeiro, said their experiments have shown that injecting Aedes aegypti mosquito eggs with the Wolbachia bacterium makes the eventual adult mosquitoes highly resistant to the Zika virus, thereby limiting their ability to spread it.

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First Commercial Zika Virus Test Gets FDA Approval

CLICK HERE - Quest Diagnostics - Zika Virus Infection - Important Testing Information and Helpful Resources

nbcnews.com - by Maggie Fox - April 28, 2016

The first commercial U.S. test to diagnose Zika virus won emergency use authorization from the Food and Drug Administration Thursday.

It's a rare piece of good news as states and the federal government struggle to get out ahead of the Zika virus epidemic as it makes its way north to the U.S.

Quest Diagnostics says it should be able to handle any demand for the test, which uses the same method that government labs use to look for Zika virus in a patient's blood.

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Texas - First Confirmed Case of Sexually Transmitted Zika in U.S.

          

Dallas County Health and Human Services confirms its first case of Zika virus transmitted through sexual activity

CLICK HERE - Dallas County Health and Human Services - DCHHS Reports First Zika Virus Case in Dallas County Acquired Through Sexual Transmission (2 page .PDF file)

cnn.com - by Sandee LaMotte - February 2, 2016

The first case of locally acquired Zika in the continental United States has occurred through sexual transmission in Texas, the Centers for Disease Control and Prevention said Tuesday.

The case, announced by Dallas County health officials, involved a patient who had sex with someone who had recently returned from Venezuela infected with the mosquito-borne virus.

In a statement to CNN, the CDC said it confirmed the test results showing Zika present in the blood of a "nontraveler in the continental United States." They stressed that there was no risk to a developing fetus in this instance.

Based on that, the CDC says it will soon provide guidance on sexual transmission, with a "focus on the male sexual partners of women who are or who may be pregnant."

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Zika Virus - WHO Declares a Public Health Emergency of International Concern

                                               

WHO Director-General summarizes the outcome of the Emergency Committee on Zika

who.int - February 1, 2016

WHO statement on the first meeting of the International Health Regulations (2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations 

I convened an Emergency Committee, under the International Health Regulations, to gather advice on the severity of the health threat associated with the continuing spread of Zika virus disease in Latin America and the Caribbean. The Committee met today by teleconference.

In assessing the level of threat, the 18 experts and advisers looked in particular at the strong association, in time and place, between infection with the Zika virus and a rise in detected cases of congenital malformations and neurological complications.

The experts agreed that a causal relationship between Zika infection during pregnancy and microcephaly is strongly suspected, though not yet scientifically proven. All agreed on the urgent need to coordinate international efforts to investigate and understand this relationship better.

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Texas Woman Diagnosed With Mosquito-Borne Zika Virus

             

Dengue fever, chikungunya virus and Zika virus are spread by the bite of infected Aedes aegypti and Aedes albopictus mosquitoes. PHOTO: UNIVERSAL HISTORY ARCHIVE/UIG/GETTY IMAGES

wsj.com - by BETSY MCKAY and REED JOHNSON - January 12, 2016

A Houston-area woman who traveled in November to El Salvador has been diagnosed with the Zika virus, public health officials said, raising concern that the mosquito-borne illness linked to a health crisis in Brazil could spread through the Americas. . . .

. . . The Texas case shows how the Zika virus is spreading after sparking an epidemic in Brazil that has led to an estimated 500,000 to 1.5 million cases, public health officials say.

Health officials in Brazil believe the virus is behind thousands of cases of microcephaly in that country—a condition in which infants are born with undersized brains and skulls—though it hasn’t before been linked to that rare condition. . . .

. . . U.S. officials say they are preparing for a possible influx of Zika this spring and summer, when populations of the mosquitoes that transmit it—Aedes aegypti and Aedes albopictus—flourish. . . .

. . . The department is also urging people to protect themselves from mosquitoes.

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HHS selects nine regional Ebola and other special pathogen treatment centers

New network expands US ability to respond to outbreaks of severe, highly infectious diseases

DEPARTMENT OF HEALTH AND HUMAN SERVICES            June 12, 2015

WASHINGTON -- To further strengthen the nation’s infectious disease response capability, the U.S. Department of Health and Human Services has selected nine health departments and associated partner hospitals to become special regional treatment centers for patients with Ebola or other severe, highly infectious diseases.

HHS’ Office of the Assistant Secretary for Preparedness and Response (ASPR) has awarded approximately $20 million through its Hospital Preparedness Program (HPP) to enhance the regional treatment centers’ capabilities to care for patients with Ebola or other highly infectious diseases. ASPR will provide an additional $9 million to these recipients in the subsequent four years to sustain their readiness...

The nine awardees and their partner hospitals are:

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What Did the U.S. Learn from Ebola? How to Prepare for Bioterrorist Attacks

FOREIGN POLICY  by Siobhán O'Grady                        April 13, 2015
When the Ebola virus spread from Guinea to Sierra Leone and Liberia last spring, the initial international response was labeled a failure. By the time President Barack Obama ordered troops to the affected countries in September, more than 2,400 people were dead.

But in the United States, where major hospitals prepared for an outbreak, there were only four in-country diagnoses, one of which resulted in a death. And some see the urgency of that response as a lesson in how the government can prepare for another public health hazard: a bioterrorist attack.

Arizona Rep. Martha McSally chairs a House subcommittee that will examine over the next few months the threat of bioterrorist attacks and U.S. preparedness to respond to them. She told Foreign Policy that even if a disease outbreak and the use of a biological agent in a coordinated attack are not completely analogous, the response strains similar systems.

“We can learn lessons from other outbreaks that are naturally occurring,” she said. “We can identify weaknesses in our response and even if it wasn’t terrorism, it presses the system at the same level....”

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Tekmira Ebola drug succeeds in small monkey study

REUTERS by Aharon Begley                                                                    Aug. 22, 2015
NEW YORK --An experimental Ebola drug from Tekmira Pharmaceuticals Corp cured all three monkeys intentionally infected with the virus, scientists reported on Wednesday, the first such success against the strain of Ebola in West Africa's 2014-2015 outbreak.

Although other experimental treatments appeared to help Ebola patients last year, especially in the United States, those one-time uses cannot prove efficacy against the "Makona" strain, since patients' recovery might be due to other causes. Similarly, drugs, including Mapp Biopharmaceutical's ZMapp, cured monkeys in lab experiments, but in a strain of Ebola different from that responsible for the current outbreak, the worst ever recorded.

"We can't say for certain that an experimental drug that works against one strain will work in another, even if they're almost identical genetically," said Thomas Geisbert of the University of Texas Medical Branch, senior author of the study published in the journal Nature.

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2 new ebola vaccines pass important early test, researchers say

NEW YORK TIMES   by Denis Grady                                                                 April 9. 2015

Two  new Ebola vaccines have passed an important test, protecting monkeys against the strain of the virus responsible for the current deadly outbreak, researchers reported on Wednesday. Only one dose was needed, and there were no apparent side effects..

Thomas W. Geisbert, an Ebola expert at the University of Texas Medical Branch in Galveston, in his office. Credit Michael Stravato for The New York Times

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